Stephan Mielke, M.D., Prof.
Professor of Hematology and Cellular Therapy (LabMed);
Head of Department and Senior Physician at the Center of Allogeneic Stem Cell Transplantation and Cellular Therapy (ME CAST, Tema Cancer);
Director of the Cellular Therapy and Allogeneic Stem Cell Transplantation Program (JACIE-accredited);
Member of the Board of Directors of Karolinska Comprehensive Cancer Center (OECI) and
Karolinska ATMP Center, Karolinska university hospital, Stockholm, Sweden
Bio
Stephan Mielke started as Professor of Hematology and Cell Therapy at Karolinska Institutet and Department Head and Scientific Director at the Cancer Center of Karolinska University Hospital in May 2017. He graduated in 1999 from Medical School in Göttingen. Trained in Internal Medicine, Hematology and Oncology at the University of Freiburg he was awarded a postdoctoral fellowship at the NIH, where he initiated clinical trials focusing on cellular therapy.
In 2007 he returned to Germany and became Director of the newly built Adult Allogeneic Stem Cell Transplantation Program and in 2014 Professor of Internal Medicine at the University of Würzburg. He focused on graft manipulation in haplo-identical stem cell transplantation and initiated world-wide multicenter trials with ATMPs as coordinating investigator. Mielke is one of Europe's pioneers in CAR T-cell therapy, being one of the first in Germany treating patients with CAR T-cells in 2016 as part of the JULIET trial (NEJM 2019, JCO 2026) and was the first to perform CAR T cell therapy in 2019 at Karolinska as part of the TRANSFORM trial (Lancet 2022, JCO 2025).
He has performed Sweden's first standard of care CAR T cell treatment in 2019 and has recruited several international trials to Karolinska such as the TRANSCEND FOL study (Nature Med 2024). Stephan Mielke has taken a leading role in the foundation of Karolinska Comprehensive Cancer Center (2020) as well as Karolinska ATMP Center (2024). In 2019 he founded SWECARNET, Sweden’s CAR T cell network, a co-creational cooperation between academia, healthcare and industry.